6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Base Information

Chemical Name:6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester
CAS No.:583832-72-8
Molecular Formula:C₂₆H₂₀BrNO₅
Molecular Weight:506.353
Hs Code.:

Synonyms:6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

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Chemical Property of 6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

There total 6 articles about 6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₂BrNO₆

: 583832-72-8
6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Guidance literature:: With sulfuric acid; In methanol; for 3h; Heating;
DOI:10.1016/j.bmc.2008.02.027

Reference yield:

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 583832-72-8
6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 1.5 h / 20 °C / Heating / reflux

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / acetone / 0.17 h / 20 °C

3.1: DMF (N,N-dimethyl-formamide); acetone / 20 h / 20 °C

3.2: 15 h / 120 °C

4.1: sulfuric acid / water / 2 h / Heating / reflux

5.1: methanol / 18 h / 20 °C

5.2: 3 h / Heating / reflux

With aluminum (III) chloride; sulfuric acid; potassium carbonate; In methanol; DMF (N,N-dimethyl-formamide); water; acetone;

Reference yield:

: 4-bromo-2-benzoylbenzoic acid potassium salt

: 583832-72-8
6-bromo-2-(4-methoxycarbonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMF (N,N-dimethyl-formamide); acetone / 20 h / 20 °C

1.2: 15 h / 120 °C

2.1: sulfuric acid / water / 2 h / Heating / reflux

3.1: methanol / 18 h / 20 °C

3.2: 3 h / Heating / reflux

With sulfuric acid; In methanol; DMF (N,N-dimethyl-formamide); water; acetone;