3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Base Information

Chemical Name:3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate
CAS No.:1352306-56-9
Molecular Formula:C₂HF₃O₂*C₃₀H₃₃NO₄
Molecular Weight:585.62
Hs Code.:

Synonyms:3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

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Chemical Property of 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

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Technology Process of 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

There total 12 articles about 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352427-09-8
1-((2S)-1-(4-(4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)propan-2-yl)piperidine

: 76-05-1
trifluoroacetic acid

: 1352306-56-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: 1-((2S)-1-(4-(4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)propan-2-yl)piperidine; With water; acetic acid; at 90 ℃; for 0.25h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 2785-98-0
2,5-dimethoxybenzoic acid

: 1352306-56-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: magnesium / iodine / tetrahydrofuran / 1.75 h / 60 °C

3.2: 1 h / 0 °C

4.1: boron tribromide / dichloromethane / 0.5 h / -78 - 0 °C

4.2: -78 °C

5.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C

6.1: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 2-methyl-propan-1-ol / 1.5 h / Dean-Stark trap; Reflux

7.1: tetrahydrofuran / 2.25 h / 0 - 20 °C

7.2: 0 °C

8.1: water; acetic acid / tetrahydrofuran / 90 °C

9.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

10.1: potassium carbonate; [2,2]bipyridinyl; copper(l) iodide / 140 °C / Inert atmosphere

11.1: water; acetic acid / 0.25 h / 90 °C

With piperidine; [2,2]bipyridinyl; copper(l) iodide; oxalyl dichloride; water; boron tribromide; potassium carbonate; magnesium; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; iodine; pyridinium p-toluenesulfonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 2-methyl-propan-1-ol;

Reference yield:

: 1097016-89-1
1-(2,5-dimethoxyphenyl)-2-(3-methoxyphenyl)ethanone

: 1352306-56-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-(piperidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: boron tribromide / dichloromethane / 0.5 h / -78 - 0 °C

1.2: -78 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C

3.1: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 2-methyl-propan-1-ol / 1.5 h / Dean-Stark trap; Reflux

4.1: tetrahydrofuran / 2.25 h / 0 - 20 °C

4.2: 0 °C

5.1: water; acetic acid / tetrahydrofuran / 90 °C

6.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

7.1: potassium carbonate; [2,2]bipyridinyl; copper(l) iodide / 140 °C / Inert atmosphere

8.1: water; acetic acid / 0.25 h / 90 °C

With piperidine; [2,2]bipyridinyl; copper(l) iodide; water; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; 2-methyl-propan-1-ol;