tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate

Base Information

• Chemical Name: tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate
• CAS No.: 240420-40-0
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.417
• Mol file: 240420-40-0.mol

Synonyms:tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate

Chemical Property of tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate

There total 12 articles about tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2,2-dimethyl-4-[(E)-2-phenylethenyl]-1,3-oxazolane-3-carboxylate (132652-65-4) → tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate (240420-40-0)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(02)00512-9

Reference yield: 96.0%

(E/Z)-(R)-N-Boc-2,2-dimethyl-4-(2-phenylethenyl)oxazolidine (709026-61-9) → tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate (240420-40-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2004.03.001

Reference yield: 82.0%

C21H31NO3S2 (1434253-83-4) → tert-butyl (4R)-2,2-dimethyl-4-(2-phenylethyl)-1,3-oxazolidine-3-carboxylate (240420-40-0)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In tetrahydrofuran; methanol; at 0 - 30 ℃;

DOI:10.1002/ejoc.201201128

upstream raw materials:

bromobenzene

tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate

iodobenzene

tert-butyl 2,2-dimethyl-4-[(E)-2-phenylethenyl]-1,3-oxazolane-3-carboxylate

Downstream raw materials:

tert-butyl (R)-(1-hydroxy-4-phenylbutan-2-yl)carbamate

methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-phenylbutanoate

[1-(dimethoxy-phosphoryloxymethyl)-3-phenyl-propyl]-carbamic acid tert-butyl ester

(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid