tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

Base Information

Chemical Name:tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate
CAS No.:1392437-23-8
Molecular Formula:C₃₁H₃₂ClF₄N₅O₆
Molecular Weight:682.072
Hs Code.:

tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

Synonyms:tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

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Chemical Property of tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

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Technology Process of tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

There total 8 articles about tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392437-27-2
tert-butyl(trans)-9-(4-chloro-7-methoxy-quinazolin-6-yloxy)-5-oxo-1-(2,2,2-trifluoro-acetyl)1,4-diaza-spiro[5.5]undecane-4-carboxylate

: 2106-04-9
3-chloro-2-fluoroaniline

: 1392437-23-8
tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

Guidance literature:: With hydrogenchloride; In acetonitrile; at 55 - 60 ℃; for 0.333333h; Large scale;

Reference yield:

: 1263475-11-1
1,4-dioxa-9,12-diaza-dispiro[4.2.5.2]pentadecan-13-one

: 1392437-23-8
tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; acetic acid / 1,4-dioxane / 2.58 h / 80 - 100 °C / Large scale

2.1: sodium methylate / acetonitrile; methanol / 3 h / 20 °C / Large scale

2.2: 16 h / Large scale

2.3: 1.67 h / Large scale

3.1: sodium tetrahydroborate / water / 0.53 h / 3 °C / Large scale

4.1: triethylamine / 2-methyltetrahydrofuran / 0.5 h / 3 - 25 °C / Large scale

4.2: 3 h / 52 °C / Large scale

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.67 h / 50 - 55 °C / Large scale

6.1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane; isopropyl alcohol / 4 h / 80 °C / Large scale

7.1: triphenylphosphine; N-chloro-succinimide / 1,4-dioxane; acetonitrile / 0.52 h / 60 - 90 °C / Large scale

8.1: hydrogenchloride / acetonitrile / 0.33 h / 55 - 60 °C / Large scale

With hydrogenchloride; sodium tetrahydroborate; N-chloro-succinimide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium methylate; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1263475-13-3
1,4-diaza-spiro[5.5]undecane-5,9-dione hydrochloride

: 1392437-23-8
tert-butyl (trans)-9-[4-(3-chloro-2-fluorophenylamino)-7-methoxy-quinazolin-6-yloxy]-5-oxo-1-(2,2,2-trifluoroacetyl)-1,4-diazaspiro[5.5]undecane-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / acetonitrile; methanol / 3 h / 20 °C / Large scale

1.2: 16 h / Large scale

1.3: 1.67 h / Large scale

2.1: sodium tetrahydroborate / water / 0.53 h / 3 °C / Large scale

3.1: triethylamine / 2-methyltetrahydrofuran / 0.5 h / 3 - 25 °C / Large scale

3.2: 3 h / 52 °C / Large scale

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.67 h / 50 - 55 °C / Large scale

5.1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane; isopropyl alcohol / 4 h / 80 °C / Large scale

6.1: triphenylphosphine; N-chloro-succinimide / 1,4-dioxane; acetonitrile / 0.52 h / 60 - 90 °C / Large scale

7.1: hydrogenchloride / acetonitrile / 0.33 h / 55 - 60 °C / Large scale

With hydrogenchloride; sodium tetrahydroborate; N-chloro-succinimide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium methylate; triethylamine; triphenylphosphine; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water; isopropyl alcohol; acetonitrile;