methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate

Base Information

• Chemical Name: methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate
• CAS No.: 1427066-92-9
• Molecular Formula: C₂₅H₂₁N₅O₂
• Molecular Weight: 423.474

Synonyms:methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate

Chemical Property of methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate

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Technology Process of methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate

There total 4 articles about methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N-(4-methyl-3-aminophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine (571187-03-6) + methyl 4-formylbenzoate (1571-08-0) → methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate (1427066-92-9)

Guidance literature:

In ethanol; Reflux;

DOI:10.1134/S1070428013020073

Reference yield:

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one (55314-16-4,75415-01-9,123367-26-0) → methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate (1427066-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / N,N-dimethyl-formamide; water / 6 h / 110 - 130 °C

2: hydrazine hydrate / water; methanol / 1 h / 60 °C

3: ethanol / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1134/S1070428013020073

Reference yield:

N1-amino(imino)methyl-4-methyl-3-nitroaniline nitrate (796738-68-6) → methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate (1427066-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / N,N-dimethyl-formamide; water / 6 h / 110 - 130 °C

2: hydrazine hydrate / water; methanol / 1 h / 60 °C

3: ethanol / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1134/S1070428013020073

upstream raw materials:

N,N-(4-methyl-3-aminophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine

methyl 4-formylbenzoate

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

N₁-amino(imino)methyl-4-methyl-3-nitroaniline nitrate

Downstream raw materials:

methyl 4-(2-methyl-3-{5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylamino}methyl)benzoate

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