1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline
CAS No.:258533-12-9
Molecular Formula:C₂₅H₂₇NOS
Molecular Weight:389.561
Hs Code.:

Synonyms:1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

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Technology Process of 1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

There total 5 articles about 1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 258533-11-8
1-(1,1-diphenylethylthioacetyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

: 258533-12-9
1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2005.10.050

Reference yield:

: 258533-04-9
5-(t-butoxydimethylsiloxy)quinoline

: 258533-12-9
1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / H₂ / Pd-C / ethanol / 20 °C

2: 100 percent / pyridine / CH₂Cl₂ / 5 h / 0 °C

3: 98 percent / sodium hydride / dimethylformamide / 3 h / 20 °C

4: 46 percent / BH₃-THF complex / tetrahydrofuran / 5 h / 20 °C

With pyridine; borane-THF; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050

Reference yield:

: 578-67-6
quinolin-5-ol

: 258533-12-9
1-(2-(1,1-diphenylethylthio)ethyl)-5-hydroxy-1-chloroacetyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / imidazole / dimethylformamide / 20 °C

2: 82 percent / H₂ / Pd-C / ethanol / 20 °C

3: 100 percent / pyridine / CH₂Cl₂ / 5 h / 0 °C

4: 98 percent / sodium hydride / dimethylformamide / 3 h / 20 °C

5: 46 percent / BH₃-THF complex / tetrahydrofuran / 5 h / 20 °C

With pyridine; 1H-imidazole; borane-THF; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050