1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 1588551-00-1
• Molecular Formula: C₅₅H₇₅N₇O₁₀
• Molecular Weight: 994.241
• Mol file: 1588551-00-1.mol

Synonyms:1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

There total 4 articles about 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)(4-bromomethylbenzyl)amine (1588550-98-4) + tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide → 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (1588551-00-1)

Guidance literature:

With potassium carbonate; In chloroform; acetonitrile; for 4h; Reflux;

DOI:10.3390/molecules181113940

Reference yield:

N-(2-Aminoethyl)-1,3-propanediamine (13531-52-7) → 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (1588551-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 1 h / Reflux

2: sodium carbonate / chloroform; water

3: potassium carbonate / chloroform; acetonitrile / 0.5 h / Reflux

4: potassium carbonate / chloroform; acetonitrile / 4 h / Reflux

With sodium carbonate; potassium carbonate; In chloroform; water; acetic acid; acetonitrile;

DOI:10.3390/molecules181113940

Reference yield:

diphthalimidodiethylammonium hydrogen phthalate (1588550-97-3) → 1-{4-[(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (1588551-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / chloroform; water

2: potassium carbonate / chloroform; acetonitrile / 0.5 h / Reflux

3: potassium carbonate / chloroform; acetonitrile / 4 h / Reflux

With sodium carbonate; potassium carbonate; In chloroform; water; acetonitrile;

DOI:10.3390/molecules181113940

upstream raw materials:

(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)(4-bromomethylbenzyl)amine

diphthalimidodiethylammonium hydrogen phthalate

1,4-bis(bromomethyl)benzene

(2-phthalimidoethyl)(3-phthalimidoprop-1-yl)amine

Downstream raw materials:

1-{4-[(2-aminoethyl)(3-aminoprop-1-yl)aminomethyl]phenylmethyl}-4,7,10-tris(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane