2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol

Base Information

• Chemical Name: 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol
• CAS No.: 181810-19-5
• Molecular Formula: C₂₃H₂₄FNO₄S
• Molecular Weight: 429.512
• Mol file: 181810-19-5.mol

Synonyms:2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol

Chemical Property of 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol

There total 6 articles about 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-butoxy-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)nicotinic acid → 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol (181810-19-5)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.1c00890

Reference yield:

2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-carbonitrile (181809-89-2) → 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-carboxaldehyde (181810-20-8) + 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol (181810-19-5)

Guidance literature:

With diisobutylaluminium hydride; In methanol; water; toluene;

Reference yield:

2-butoxy-6-chloronicotinic acid → 2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-methanol (181810-19-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 80 °C / Inert atmosphere

2: N-Bromosuccinimide; trifluoroacetic acid / acetonitrile / 20 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 80 °C / Inert atmosphere

4: borane-THF / tetrahydrofuran / 3 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 1: |Suzuki Coupling / 3: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.1c00890

upstream raw materials:

2-butoxy-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-carbonitrile

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

2-Butoxy-6-(4-fluorophenyl)-3-(methoxymethyl)-5-[4-(methylsulfonyl)phenyl]pyridine