Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Base Information

• Chemical Name: Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
• CAS No.: 1391026-03-1
• Molecular Formula: C₁₄H₉ClFNO₃
• Molecular Weight: 293.682
• Mol file: 1391026-03-1.mol

Synonyms:Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Chemical Property of Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

There total 4 articles about Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

propargyl alcohol (107-19-7) + 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride (69399-79-7) → Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (1391026-03-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1002/jhet.837

Reference yield:

2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride (51088-25-6) → Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (1391026-03-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10

1.2: 2 h / 0 - 20 °C / pH 9

2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

3.1: phosphorus pentachloride / 1 h / 45 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With phosphorus pentachloride; water; triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1002/jhet.837

Reference yield:

N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine (443-33-4) → Prop-2-ynyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (1391026-03-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chlorine / methanol / 0 - 5 °C

2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10

2.2: 2 h / 0 - 20 °C / pH 9

3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

4.1: phosphorus pentachloride / 1 h / 45 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With phosphorus pentachloride; water; chlorine; triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1002/jhet.837

upstream raw materials:

2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride

N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine

propargyl alcohol

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

Downstream raw materials:

(1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-caroboxylate

(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

(1-allyl-1H-1,2,3-triazol-4-yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4 carboxylate

(1-butyl-1H-1,2,3-triazol-4yl)methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate