3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

Base Information

• Chemical Name: 3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene
• CAS No.: 133295-99-5
• Molecular Formula: C₂₁H₁₁F₄NO₃S
• Molecular Weight: 433.383
• Mol file: 133295-99-5.mol

Synonyms:3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

Chemical Property of 3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

There total 1 articles about 3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene (131589-59-8) → 3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene (133295-99-5)

Guidance literature:

With hydrogen; palladium/alumina; In ethyl acetate; triethylamine; at 0 ℃; for 2.5h; in the dark;

DOI:10.1021/jo00009a037

Reference yield:

3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene (133295-99-5) → 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)-7-iodobenzothiophene

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂; 2.) NaN₃ / 1.) TFA; 0 deg C, 30 min; 2.) 70 min

2: 79 percent / I₂, morpholine / benzene / 9 h / 20 °C / in the dark

With morpholine; sodium azide; iodine; sodium nitrite; In benzene;

DOI:10.1021/jo00009a037

Reference yield:

3-(4-Amino-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene (133295-99-5) → 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene (131589-59-8)

Guidance literature:

With sodium azide; sodium nitrite; Yield given. Multistep reaction; 1.) TFA; 0 deg C, 30 min; 2.) 70 min;

DOI:10.1021/jo00009a037

upstream raw materials:

3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

Downstream raw materials:

3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene