(1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid

Base Information

Chemical Name:(1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid
CAS No.:104531-15-9
Molecular Formula:C₉H₁₀ClF₃O₂
Molecular Weight:242.625
Hs Code.:

Synonyms:(1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid

Suppliers and Price of (1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of (1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid

There total 6 articles about (1R,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 107686-54-4,187592-70-7
4-(1,1-Dichloro-2,2,2-trifluoro-ethyl)-6,6-dimethyl-3-oxa-bicyclo[3.1.0]hexan-2-one

: 68086-36-2,68127-59-3,68127-60-6,68127-61-7,72257-63-7,72257-64-8,72748-35-7,72748-68-6,74111-94-7,74111-95-8,74609-46-4,76023-99-9,76647-97-7,82796-20-1,83212-82-2,87725-85-7,90129-56-9,104531-12-6,104531-15-9,122045-31-2,122406-91-1
(+/-)-cis-3-<(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl>-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: With zinc; In N,N-dimethyl-formamide; at 60 ℃; for 3h;
DOI:10.1016/S0040-4039(00)84469-X

Reference yield:

: 103654-93-9
2,2-dichloro-1,1,1-trifluoro-5-methyl-4-hexen-3-ol

: 68086-36-2,68127-59-3,68127-60-6,68127-61-7,72257-63-7,72257-64-8,72748-35-7,72748-68-6,74111-94-7,74111-95-8,74609-46-4,76023-99-9,76647-97-7,82796-20-1,83212-82-2,87725-85-7,90129-56-9,104531-12-6,104531-15-9,122045-31-2,122406-91-1
(+/-)-cis-3-<(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl>-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / sodium acetate / 4 h / 80 °C

2: 82 percent / triethylamine, tosyl azide, 1.2 M sodium hydroxide / acetonitrile; H₂O / 1.5 h / Ambient temperature

3: 75 percent / copper(II) acetylacetone / dioxane / 2.5 h / Heating

4: zinc / dimethylformamide / 3 h / 60 °C

With sodium hydroxide; 4-toluenesulfonyl azide; sodium acetate; triethylamine; zinc; copper acetylacetonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/bcsj.60.4385

Reference yield:

: 107686-52-2
4-(2,4-dioxobutoxy)-5,5-dichloro-6,6,6-trifluoro-2-methyl-2-hexene

: 68086-36-2,68127-59-3,68127-60-6,68127-61-7,72257-63-7,72257-64-8,72748-35-7,72748-68-6,74111-94-7,74111-95-8,74609-46-4,76023-99-9,76647-97-7,82796-20-1,83212-82-2,87725-85-7,90129-56-9,104531-12-6,104531-15-9,122045-31-2,122406-91-1
(+/-)-cis-3-<(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl>-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / triethylamine, tosyl azide, 1.2 M sodium hydroxide / acetonitrile; H₂O / 1.5 h / Ambient temperature

2: 75 percent / copper(II) acetylacetone / dioxane / 2.5 h / Heating

3: zinc / dimethylformamide / 3 h / 60 °C

With sodium hydroxide; 4-toluenesulfonyl azide; triethylamine; zinc; copper acetylacetonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/bcsj.60.4385