Technology Process of 4-(1,1,3,3-tetramethyl-1,3-disilaindan-5-ylethynyl)benzoic acid
There total 8 articles about 4-(1,1,3,3-tetramethyl-1,3-disilaindan-5-ylethynyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-(1,1,3,3-tetramethyl-1,3-disilaindan-5-ylethynyl)benzoate;
With
potassium hydroxide;
In
methanol; water;
for 2h;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
methanol; water; ethyl acetate;
Inert atmosphere;
DOI:10.1039/c2ob25989c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium trimethylsilanolate / dichloromethane / 0.67 h / 0 °C / Inert atmosphere
2.1: isopentyl nitrite; diiodomethane / 22 h / 20 °C / Inert atmosphere
3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere
4.1: potassium hydroxide / methanol; water / 2 h / Inert atmosphere; Reflux
4.2: Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diiodomethane; sodium trimethylsilanolate; triethylamine; potassium hydroxide; isopentyl nitrite;
In
methanol; dichloromethane; water;
2.1: |Sandmeyer Reaction / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c2ob25989c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; potassium dichromate / water; acetone / 18 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine; diphenyl phosphoryl azide / toluene / 17 h / Inert atmosphere; Reflux
3.1: sodium trimethylsilanolate / dichloromethane / 0.67 h / 0 °C / Inert atmosphere
4.1: isopentyl nitrite; diiodomethane / 22 h / 20 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere
6.1: potassium hydroxide / methanol; water / 2 h / Inert atmosphere; Reflux
6.2: Inert atmosphere
With
potassium dichromate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diiodomethane; sulfuric acid; diphenyl phosphoryl azide; sodium trimethylsilanolate; triethylamine; potassium hydroxide; isopentyl nitrite;
In
methanol; dichloromethane; water; acetone; toluene;
1.1: |Jones Oxidation / 2.1: |Curtius Rearrangement / 4.1: |Sandmeyer Reaction / 5.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c2ob25989c
