6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

Base Information

Chemical Name:6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate
CAS No.:1451256-14-6
Molecular Formula:C₃₀H₃₁N₇O₆
Molecular Weight:585.619
Hs Code.:

Synonyms:6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

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Chemical Property of 6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

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Technology Process of 6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

There total 4 articles about 6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 6-{[1-(dimethylamino)ethylidene]amino}-1,9-dihydro-9-[(3-O-propargyl)-β-D-ribofuranosyl]-2H-purin-2-one

: 83-01-2
diphenylcarbamic chloride

: 1451256-14-6
6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; at 20 ℃; for 0.666667h;
DOI:10.1021/jo4012706

Reference yield:

: 1451256-12-4
6-amino-1,9-dihydro-9-[(3-O-propargyl)-β-D-ribofuranosyl]-2H-purin-2-one

: 1451256-14-6
6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / pyridine / 0.67 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In pyridine;
DOI:10.1021/jo4012706

Reference yield:

: 2096-10-8
adenosine-2-amine

: 1451256-14-6
6-{[1-(dimethylamino)ethylidene]amino}-9-[(3-Opropargyl)-β-D-ribofuranosyl]purin-2-yl-diphenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride; tetra-(n-butyl)ammonium iodide / mineral oil / 72 h / 5 - 55 °C / Inert atmosphere

2: acetic acid; sodium nitrite / water / 0.33 h / 50 °C

3: 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / pyridine / 0.67 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In pyridine; water; mineral oil;
DOI:10.1021/jo4012706