3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester

Base Information

• Chemical Name: 3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester
• CAS No.: 1186396-97-3
• Molecular Formula: C₁₈H₂₀ClNO₂
• Molecular Weight: 317.815
• Mol file: 1186396-97-3.mol

Synonyms:3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester

Chemical Property of 3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester

There total 1 articles about 3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propargyl alcohol (107-19-7) + 3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride (189949-97-1) → 3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester (1186396-97-3)

Guidance literature:

With triethylamine; In dichloromethane; Inert atmosphere;

DOI:10.1016/j.bmc.2009.06.007

Reference yield: 75.0%

3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester (1186396-97-3) + 3β-(4-chlorophenyl)tropane-2β-carboxylic acid 6-azidohexyl ester (1186397-00-1) → 1-[3β-(4-chlorophenyl)tropane-2β-carbonyloxy]-6-[4-(3β-{4-chlorophenyl}tropane-2β-carbonyloxymethyl)-[1,2,3]triazol-1-yl]hexane (1186397-23-8)

Guidance literature:

With copper(ll) sulfate pentahydrate; ascorbic acid; In water; tert-butyl alcohol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.06.007

Reference yield: 47.0%

3β-(4-chlorophenyl)tropane-2β-carboxylic acid prop-2-ynyl ester (1186396-97-3) + 3β-(4-chlorophenyl)tropane-2β-carboxylic acid 2-azidoethyl ester (1186396-99-5) → 1-[3β-(4-chlorophenyl)tropane-2β-carbonyloxy]-2-[4-(3β-{4-chlorophenyl}tropane-2β-carbonyloxymethyl)-[1,2,3]triazol-1-yl]ethane (1186397-22-7)

Guidance literature:

With copper(ll) sulfate pentahydrate; ascorbic acid; In water; tert-butyl alcohol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.06.007

upstream raw materials:

propargyl alcohol

3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride

Downstream raw materials:

1-[3β-(4-chlorophenyl)tropane-2β-carbonyloxy]-2-[4-(3β-{4-chlorophenyl}tropane-2β-carbonyloxymethyl)-[1,2,3]triazol-1-yl]ethane

1-[3β-(4-chlorophenyl)tropane-2β-carbonyloxy]-6-[4-(3β-{4-chlorophenyl}tropane-2β-carbonyloxymethyl)-[1,2,3]triazol-1-yl]hexane

1-[3β-(4-chlorophenyl)tropane-2β-carbonyloxy]-7-[4-(3β-{4-chlorophenyl}tropane-2β-carbonyloxymethyl)-[1,2,3]triazol-1-yl]heptane