(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

Base Information

Chemical Name:(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine
CAS No.:184044-75-5
Molecular Formula:C₁₉H₂₀FNO₂
Molecular Weight:313.372
Hs Code.:

Synonyms:(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

Chemical Property:

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Technology Process of (3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

There total 7 articles about (3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: (R)-3-Fluoro-2-((E)-3-phenyl-allyloxy)-propionaldehyde

: 184044-75-5
(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

Guidance literature:: With sodium carbonate; In methanol; at 20 ℃; for 2h; Heating;
DOI:10.1080/00397919808004836

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 184044-75-5
(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / aq. NaOH / tetrabutylammonium hydrogenosulfate / CH₂Cl₂ / 20 h / 20 °C

2: 2,4,6-trimethylpyridine / acetonitrile / 0.83 h / 0 °C

3: aq. K₂CO₃; aq. CuCl₂ / acetonitrile / 2 h / 20 °C

4: 65 percent / Na₂CO₃ / methanol / 2 h / 20 °C / Heating

With 2,4,6-trimethyl-pyridine; sodium hydroxide; sodium carbonate; potassium carbonate; copper dichloride; tetra(n-butyl)ammonium hydrogensulfate; In methanol; dichloromethane; acetonitrile; 1: Alkylation / 2: Rummerer rearrangement / 3: Hydrolysis / 4: Addition;
DOI:10.1080/00397919808004836

Reference yield:

: Trifluoro-acetic acid (S)-3-fluoro-2-((E)-3-phenyl-allyloxy)-1-p-tolylsulfanyl-propyl ester

: 184044-75-5
(3R,3aS,6R,6aR)-furo[3,4-c]isoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃; aq. CuCl₂ / acetonitrile / 2 h / 20 °C

2: 65 percent / Na₂CO₃ / methanol / 2 h / 20 °C / Heating

With sodium carbonate; potassium carbonate; copper dichloride; In methanol; acetonitrile; 1: Hydrolysis / 2: Addition;
DOI:10.1080/00397919808004836