1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

Base Information

Chemical Name:1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione
CAS No.:1244694-47-0
Molecular Formula:C₂₉H₃₀N₂O₄S
Molecular Weight:502.634
Hs Code.:

Synonyms:1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

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Chemical Property of 1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

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Technology Process of 1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

There total 7 articles about 1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 924896-79-7
(Z)-3-[1-(2-methylbenzo[b]thiophen-3-yl)ethylidene]-4-(propan-2-ylidene)dihydrofuran-2,5-dione

: 71026-66-9
N-(tert-butoxycarbonyl)-1,4-phenylenediamine

: 1244694-47-0
1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

Guidance literature:: (Z)-3-[1-(2-methylbenzo[b]thiophen-3-yl)ethylidene]-4-(propan-2-ylidene)dihydrofuran-2,5-dione; N-(tert-butoxycarbonyl)-1,4-phenylenediamine; In benzene; for 20h; Reflux;

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1007/s11172-008-0187-4

Reference yield:

: C₂₀H₂₂O₄S

: 1244694-47-0
1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 6 h / Reflux

2.1: acetyl chloride / dichloromethane / 3 h / 20 °C

3.1: benzene / Reflux

3.2: 5 h / 20 °C

With acetyl chloride; potassium hydroxide; In ethanol; dichloromethane; water; benzene;
DOI:10.1007/s11172-010-0099-y

Reference yield:

: 1195-14-8
2-Methylbenzothiophene

: 1244694-47-0
1-{4-[(tert-butoxycarbonyl)amino]phenyl}-4-isopropylidene-3-[(Z)-1-(2-methyl-3-benzothienyl)ethylidene]pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: tin(IV) chloride / benzene / 3.5 h / 5 - 20 °C

2.1: potassium tert-butylate / toluene / 8 h / 20 °C

2.2: pH 1

3.1: potassium hydroxide / ethanol; water / 6 h / Reflux

4.1: acetyl chloride / dichloromethane / 3 h / 20 °C

5.1: benzene / Reflux

5.2: 5 h / 20 °C

With potassium tert-butylate; tin(IV) chloride; acetyl chloride; potassium hydroxide; In ethanol; dichloromethane; water; toluene; benzene; 1.1: Fridedel Crafts acylation / 2.1: Stobbe condensation / 2.2: Stobbe condensation;
DOI:10.1007/s11172-010-0099-y