N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

Base Information

Chemical Name:N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide
CAS No.:109611-59-8
Molecular Formula:C₄₄H₆₁NO₅Si
Molecular Weight:712.058
Hs Code.:

N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

Synonyms:N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

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Chemical Property of N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

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Technology Process of N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

There total 2 articles about N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 82495-82-7
(2S)-(Z,E)-N,N-benzyl-2-<6-(2'-trimethylsilyl)ethoxy-4,5-dimethyl-1-phenyl>hexa-3,5-dienylamine

: 109611-57-6
3-Oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyric acid methyl ester

: 109611-59-8
N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

Guidance literature:: With sodium hydrogencarbonate; In toluene; for 36h; Heating;

Reference yield:

: 4-((3aR,4R,5S,7S,7aS)-5-Allyl-5-benzenesulfonyl-2,2,3a,7-tetramethyl-hexahydro-benzo[1,3]dioxol-4-yl)-3-oxo-butyric acid methyl ester

: 109611-59-8
N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / KOt-Bu / tetrahydrofuran / 1 h / 0 °C

2: 94 percent / NaHCO₃ / toluene / 36 h / Heating

With potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; toluene;

Reference yield:

: 109611-59-8
N-Benzyl-N-[(2Z,4E)-(S)-1-benzyl-3,4-dimethyl-5-(2-trimethylsilanyl-ethoxy)-penta-2,4-dienyl]-3-oxo-4-[(3aR,4S,7S,7aS)-2,2,3a,7-tetramethyl-5-prop-2-en-(E)-ylidene-hexahydro-benzo[1,3]dioxol-4-yl]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, 2.) Ac₂O, pyridine, DMAP / 1.) 25 deg C, 20 h, 2.) -78 deg C, 16 h -> reflux, 24 h

2: 1.) OsO₄, 4-methylmorpholine 4-oxide, 2.) NaIO₄ / 1.) dioxane-water, THF, 24 h, 2.) 4 h

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; acetic anhydride; 4-methylmorpholine N-oxide; triethylamine;