3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

Base Information

Chemical Name:3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide
CAS No.:1263265-86-6
Molecular Formula:C₃₅H₅₁ClN₄O₆S
Molecular Weight:691.332
Hs Code.:

3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

Synonyms:3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

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Chemical Property of 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

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Technology Process of 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

There total 12 articles about 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1178045-91-4
N-(2,2-dimethoxyethyl)cyclopentylamine

: 1263265-66-2
3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid

: 1263265-86-6
3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

Guidance literature:: N-(2,2-dimethoxyethyl)cyclopentylamine; 3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid; With triethylamine; In dichloromethane; at 13 - 22 ℃; for 2.16667h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; dichloromethane; at 22 ℃; for 1.66667h; Product distribution / selectivity;

Reference yield:

: 1179338-47-6
2-(2-chloro-3-(hydroxymethyl)phenyl)ethanol

: 1263265-86-6
3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / chloroform / 2 h / Reflux

2.1: triethylamine / tetrahydrofuran / 0.5 h

2.2: 2 h

3.1: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h

5.1: triethylamine / dichloromethane / 2.17 h / 13 - 22 °C

5.2: 1.67 h / 22 °C

With manganese(IV) oxide; N-benzyl-trimethylammonium hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 1263265-05-9
tert-butyl 4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1263265-86-6
3-(2-chloro-3-((4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclopentyl-N-(2,2-dimethoxyethyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 22 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.5 h

2.2: 2 h

3.1: N-benzyl-trimethylammonium hydroxide / acetonitrile; water / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h

5.1: triethylamine / dichloromethane / 2.17 h / 13 - 22 °C

5.2: 1.67 h / 22 °C

With N-benzyl-trimethylammonium hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;