2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one

Base Information

• Chemical Name: 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one
• CAS No.: 129946-23-2
• Molecular Formula: C₁₅H₁₄N₂O₃S
• Molecular Weight: 302.354

Synonyms:2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one

Chemical Property of 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one

Chemical Property:

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Technology Process of 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one

There total 2 articles about 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,3-dihydro-1,2,5-benzothiadiazepin-4(5H)-one (146529-19-3) → 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-4-one (129946-23-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1248/cpb.40.2442

Reference yield:

2-[(2-nitrobenzene)sulfonamido]acetic acid (15054-42-9) → 2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-4-one (129946-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 42.7 percent / AcOH, Zn, ZnCl₂ / 7 h / Heating

2: 84 percent / K₂CO₃ / dimethylformamide / 20 h / Ambient temperature

With potassium carbonate; acetic acid; zinc(II) chloride; zinc; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.2442

Reference yield:

2-Benzyl-1,1-dioxo-1,2,3,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-4-one (129946-23-2) → 2-Benzyl-1,1-dioxo-5-(2-piperidin-1-yl-ethyl)-1,2,3,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-4-one

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF, RT, 2 h, 2.) DMF, 60 deg C, 5 h;

DOI:10.1248/cpb.40.2442

upstream raw materials:

2,3-dihydro-1,2,5-benzothiadiazepin-4(5H)-one

2-[(2-nitrobenzene)sulfonamido]acetic acid

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