(R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride

Base Information

• Chemical Name: (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride
• CAS No.: 960234-88-2
• Molecular Formula: C₁₅H₂₀N₂O₄S*ClH
• Molecular Weight: 360.862
• Mol file: 960234-88-2.mol

Synonyms:(R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride

Chemical Property of (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride

There total 1 articles about (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-tert-butyl 2-(2-(cyclopropylsulfonyl)-5-(methoxycarbonylamino)phenyl)pyrrolidine-1-carboxylate (960234-86-0) → (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride (960234-88-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

C17H14FN3O4 (1036390-05-2) + (R)-methyl 4-(cyclopropylsulfonyl)-3-(pyrrolidin-2-yl)phenylcarbamate hydrochloride (960234-88-2) → methyl 4-(cyclopropylsulfonyl)-3-((R)-1-((R)-2-(4-fluoro-3-methoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)phenylcarbamate (1036388-02-9) + methyl 4-(cyclopropylsulfonyl)-3-((R)-1-((S)-2-(4-fluoro-3-methoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)phenylcarbamate (1036390-07-4)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃;

upstream raw materials:

(R)-tert-butyl 2-(2-(cyclopropylsulfonyl)-5-(methoxycarbonylamino)phenyl)pyrrolidine-1-carboxylate

Downstream raw materials:

methyl 4-(cyclopropylsulfonyl)-3-((R)-1-((R)-2-(4-fluoro-3-methoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)phenylcarbamate

methyl 4-(cyclopropylsulfonyl)-3-((R)-1-((S)-2-(4-fluoro-3-methoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)phenylcarbamate