(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Base Information

Chemical Name:(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran
CAS No.:302799-52-6
Molecular Formula:C₃₁H₃₃Cl₃O₇
Molecular Weight:623.958
Hs Code.:

Synonyms:(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

There total 1 articles about (3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 3254-17-9
3,4,6-tri-O-acetyl-1,2-O-(1-ethoxyethylidene)-α-D-glucopyranose

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 302799-52-6
(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/ol0061743

Reference yield: 85.0%

: 302799-52-6
(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

: 302799-53-7
2-O-acetyl-1,5-anhydro-3,4,6-tri-O-(p-chlorobenzyl)-D-arabino-hex-1-enitol

Guidance literature:: With bromobenzene; In pyridine; Heating;
DOI:10.1021/ol0061743

Reference yield:

: 302799-52-6
(3aR,5R,6R,7S,7aR)-6,7-Bis-(4-chloro-benzyloxy)-5-(4-chloro-benzyloxymethyl)-2-ethoxy-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

: 302799-54-8
3,4,6-tri-O-(p-chlorobenzyl)-α-D-arabino-hexopyranos-2-ulosyl bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / PhBr / pyridine / Heating

2: 91 percent / NBS / ethanol; CH₂Cl₂

With N-Bromosuccinimide; bromobenzene; In pyridine; ethanol; dichloromethane; 1: Rearrangement / 2: Bromination;
DOI:10.1021/ol0061743