2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile

Base Information

• Chemical Name: 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile
• CAS No.: 1027309-46-1
• Molecular Formula: C₁₅H₁₄N₂S
• Molecular Weight: 254.356

Synonyms:2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile

Chemical Property of 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile

There total 2 articles about 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tetrahydro-2-imino-3-(3-oxobutyl)-4-phenyl-3-thiophenecarbonitrile (777939-14-7) → 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile (1027309-46-1)

Guidance literature:

With titanium tetrachloride; triethylamine; In chloroform; at 20 ℃; for 8h;

DOI:10.1002/jhet.5570410428

Reference yield:

2-amino-4,5-dihydro-4-phenyl-3-thiophenecarbonitrile (85508-72-1) → 2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile (1027309-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / titanium(IV) chloride / CHCl₃ / 5 h / 20 °C

2: 60 percent / titanium(IV) chloride; triethylamine / CHCl₃ / 8 h / 20 °C

With titanium tetrachloride; triethylamine; In chloroform; 1: Michael reaction;

DOI:10.1002/jhet.5570410428

Reference yield: 93.0%

2,3,3a,4-tetrahydro-6-methyl-3-phenylthieno[2,3-b]pyridine-3a-carbonitrile (1027309-46-1) → 2,3-dihydro-6-methyl-3-phenylthieno[2,3-b]pyridine

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 1h; Heating;

DOI:10.1002/jhet.5570410428

upstream raw materials:

tetrahydro-2-imino-3-(3-oxobutyl)-4-phenyl-3-thiophenecarbonitrile

2-amino-4,5-dihydro-4-phenyl-3-thiophenecarbonitrile

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