5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Base Information

Chemical Name:5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester
CAS No.:300568-77-8
Molecular Formula:C₄₁H₄₈N₂O₆Si
Molecular Weight:692.927
Hs Code.:

5-(benzyloxycarbonyl-methyl-amino)-1-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-<i>a</i>]isoindole-4-carboxylic acid 9<i>H</i>-fluoren-9-yl ester

Synonyms:5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Suppliers and Price of 5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

There total 9 articles about 5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 300568-75-6
{(2R,3S)-2-[(1R,3S)-3-(Benzyloxycarbonyl-methyl-amino)-2-oxo-cyclohexyl]-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid 9H-fluoren-9-yl ester

: 300568-77-8
5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Guidance literature:: With triethyl phosphite; In various solvent(s); for 5h; Heating;
DOI:10.1016/S0040-4020(00)00414-2

Reference yield:

: 1689-64-1
9-Fluorenol

: 300568-77-8
5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.5 h / 0 °C

2: 94.6 percent / potassium carbonate; pyridine / CH₂Cl₂ / 0 - 25 °C

3: 88.5 percent / P(OEt)3 / various solvent(s) / 5 h / Heating

With pyridine; potassium carbonate; triethyl phosphite; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Acylation / 3: Cyclization;
DOI:10.1016/S0040-4020(00)00414-2

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 300568-77-8
5-(benzyloxycarbonyl-methyl-amino)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid 9H-fluoren-9-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / diisopropylamine / CH₂Cl₂ / 2 h / 0 °C

2: 79 percent / oxalyl chloride; dimethyl sulfoxide / CH₂Cl₂ / 1 h / -70 °C

3: 94.6 percent / potassium carbonate; pyridine / CH₂Cl₂ / 0 - 25 °C

4: 88.5 percent / P(OEt)3 / various solvent(s) / 5 h / Heating

With pyridine; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; diisopropylamine; triethyl phosphite; In dichloromethane; 1: Acylation / 2: Oxidation / 3: Acylation / 4: Cyclization;
DOI:10.1016/S0040-4020(00)00414-2