(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Base Information

Chemical Name:(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol
CAS No.:1316841-28-7
Molecular Formula:C₂₂H₃₀O₅
Molecular Weight:374.477
Hs Code.:

Synonyms:(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Suppliers and Price of (2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Chemical Property:

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Technology Process of (2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

There total 25 articles about (2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1316841-38-9
(2S,3R)-1,1-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-4-butanal

: 1316841-28-7
(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo200968f

Reference yield: 65.0%

: (2R,3S)-4,4-bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethyl-1-butanol

: 77-78-1
dimethyl sulfate

: 1316841-28-7
(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Guidance literature:: With dibenzo-18-crown-6; potassium carbonate; In acetonitrile; at 80 ℃; for 24h;
DOI:10.1080/09168451.2014.877833

Reference yield:

: C₇H₁₁IO₂

: 1316841-28-7
(2R,3S)-4,4-bis(3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; zinc / 18 h / 60 °C

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 22 h / 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 48 h / 20 °C

7.1: sodium periodate / methanol; water / 0.5 h

8.1: sodium tetrahydroborate / methanol / -78 - 20 °C / Inert atmosphere

With triethylsilane; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; boron trifluoride diethyl etherate; water; tert.-butyl lithium; acetic acid; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; pentane;
DOI:10.1021/jo200968f