5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine

Base Information

• Chemical Name: 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine
• CAS No.: 1376766-41-4
• Molecular Formula: C₂₇H₂₈ClN₅O₂
• Molecular Weight: 490.005
• Mol file: 1376766-41-4.mol

Synonyms:5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine

Chemical Property of 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine

There total 3 articles about 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-chloro-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester (36746-07-3) + N1-(7-chloroquinolin-4-yl)butane-1,4-diamine (53186-45-1) → 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine (1376766-41-4)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2012.03.007

Reference yield:

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8) → 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine (1376766-41-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 24 h

2: trichlorophosphate / 105 °C

3: potassium carbonate / tetrahydrofuran / 48 h / 20 °C

With potassium carbonate; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2012.03.007

Reference yield:

ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate (69207-36-9) → 5-ethoxycarbonyl-6-methyl-4-phenyl-2-[4-(7-chloroquinolin-4-ylamino)butylamino]pyrimidine (1376766-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 105 °C

2: potassium carbonate / tetrahydrofuran / 48 h / 20 °C

With potassium carbonate; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2012.03.007

upstream raw materials:

2-chloro-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester

N₁-(7-chloroquinolin-4-yl)butane-1,4-diamine

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate