4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine

Base Information

Chemical Name:4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine
CAS No.:365428-85-9
Molecular Formula:C₁₇H₁₄F₃N₃S
Molecular Weight:349.379
Hs Code.:
DSSTox Substance ID:DTXSID10469068
Wikidata:Q82296643

Synonyms:4-[2-ETHYL-4-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL]-2-PYRIDYLAMINE;365428-85-9;SCHEMBL3890192;DTXSID10469068;BXWBICFQVWWWDF-UHFFFAOYSA-N

Suppliers and Price of 4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:349.08605312
Heavy Atom Count:24
Complexity:420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC(=NC=C2)N)C3=CC(=CC=C3)C(F)(F)F

Technology Process of 4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine

There total 5 articles about 4-[2-Ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-YL]-2-pyridylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2-(2-amino-4-pyridyl)-2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone hydrobromide

: 631-58-3
thiopropanamide

: 365428-85-9
4-{2-ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 2-methyl-1-[3-(trifluoromethyl)benzoyl]aziridine

: 365428-85-9
4-{2-ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 70 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 93 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 72 percent / dimethylformamide / 14 h / 20 °C

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 365427-99-2
tert-butyl (4-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}-2-pyridyl)carbamate

: 365428-85-9
4-{2-ethyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Br₂; AcOH / 3 h / 80 °C

2: 72 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o