[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

Base Information

Chemical Name:[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester
CAS No.:221555-22-2
Molecular Formula:C₂₆H₄₃N₇O₉
Molecular Weight:597.669
Hs Code.:

[2-(2-{[2-(6-<i>tert</i>-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

Synonyms:[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

There total 1 articles about [2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 221555-22-2
[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HOSu, DCC, 2.) NMM / 1.) DMF, room temperature, 12 h, 2.) DMF, -15 deg C (3 h), -> room temperature (2 h)

2: 80 percent / TEA, Brop / CH₂Cl₂ / 2 h / Ambient temperature

3: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

4: 60 percent / NMM, Bop / dimethylformamide / 1.) -15 deg C, 3 h, 2.) room temperature, 2 h

With 4-methyl-morpholine; lithium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)01211-3

Reference yield: 70.0%

: 144564-95-4
[N⁴-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

: 221555-22-2
[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

: 221555-26-6
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid methyl ester

Guidance literature:: With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(98)01211-3

Reference yield:

: 221555-22-2
[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethylamino]-acetic acid methyl ester

: 221555-29-9
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Et₃N, Brop / CH₂Cl₂ / 2 h / Ambient temperature

2: 75 percent / aq. LiOH / dioxane / 1 h / 0 °C

With lithium hydroxide; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/S0040-4020(98)01211-3