HEXAMETHYLPHOSPHOROUS TRIAMIDE

Base Information

• Chemical Name: HEXAMETHYLPHOSPHOROUS TRIAMIDE
• CAS No.: 59758-27-9
• Molecular Formula: C18H42N3P
• Molecular Weight: 331.52
• Mol file: 59758-27-9.mol

Synonyms:hexaisopropyltriamidophosphite;hexaisopropylbenzene;Hexaisopropylbenzol;hexaisopropylphosphorous triamide;

Chemical Property of HEXAMETHYLPHOSPHOROUS TRIAMIDE

Chemical Property:

• Boiling Point: 357.5±11.0 °C(Predicted)
• PKA: 10.33±0.70(Predicted)
• PSA: 23.31000
• LogP: 0.89810

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HEXAMETHYLPHOSPHOROUS TRIAMIDE

There total 4 articles about HEXAMETHYLPHOSPHOROUS TRIAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

diisopropylamine (108-18-9) → hexaisopropylphosphorous triamide (59758-27-9)

Guidance literature:

With triethylamine; phosphorus trichloride; In benzene; at 0 - 20 ℃; for 24h;

DOI:10.1023/A:1020807208325

Reference yield: 25.0%

diisopropylamine (108-18-9) + phosphorous tris(N-methyl-N-trifluoroacetylamide) (153732-49-1) → hexaisopropylphosphorous triamide (59758-27-9) + phosphorous (N-methyl-N-trifluoroacetyl)bis(N',N'-diisopropyl)triamide + phosphorous bis(N-methyl-N-trifluoroacetyl)-N',N'-diisopropyltriamide

Guidance literature:

In benzene; for 12h; Heating;

Reference yield:

C18H33N2OP → diphenyl N,N-diisopropylphosphoramidite (25781-01-5) + hexaisopropylphosphorous triamide (59758-27-9)

Guidance literature:

at 20 ℃; Title compound not separated from byproducts;

DOI:10.1080/714040960

upstream raw materials:

bis(diisopropylamino)chlorophosphine

diisopropylamine

phosphorous tris(N-methyl-N-trifluoroacetylamide)

Downstream raw materials:

bis(dialkylaminophosphanyl)imine

Refernces

• 1、 Rasadkina,Slitikov,Nifant'ev. "Dismutation of arylene phosphorodiamidites: Specific features and aspects of preparative use". . p. 183 - 197. Retrieved 2008/02/08.
• 2、 Sinitsa,Nesterova,Malenko,Luk'yanenko. "Reaction of Phosphorous Tris(N-methyl-N-trifluoroacetylamides) with Amines". . p. 62 - 64. Retrieved 2007/10/03.