6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione
CAS No.:1055031-79-2
Molecular Formula:C₃₄H₄₀N₂O₄Si
Molecular Weight:568.788
Hs Code.:

Synonyms:6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

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Chemical Property of 6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

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Technology Process of 6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

There total 7 articles about 6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176519-59-8
Thiocarbonic acid O-[(2R,3S,5S)-5-(6-benzyl-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl] ester O-phenyl ester

: 1055031-79-2
6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

Guidance literature:: With azobisisobutyronitrile; tri-n-butyl-tin hydride; In toluene; at 80 ℃; for 3h;
DOI:10.1021/jm9600499

Reference yield:

: 22900-10-3,35536-75-5,36792-85-5,113890-34-9,113890-37-2,133813-23-7
2-deoxy-D-ribose

: 1055031-79-2
6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1percent HCl / 0.33 h

2: pyridine ,DMAP / 2 h

3: 12 h

4: trimethylsilyl triflate / acetonitrile / 3 h / -45 °C

5: α,α'-azoisobutyronitrile, Bu3SnH / toluene / 3 h / 80 °C

With pyridine; hydrogenchloride; dmap; trimethylsilyl trifluoromethanesulfonate; azobisisobutyronitrile; tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jm9600499

Reference yield:

: 127306-47-2
methyl-5-O-tert-butyldiphenylsilyl-2-deoxy-ribo-furanoside

: 1055031-79-2
6-Benzyl-1-[(2S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-ethyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 12 h

2: trimethylsilyl triflate / acetonitrile / 3 h / -45 °C

3: α,α'-azoisobutyronitrile, Bu3SnH / toluene / 3 h / 80 °C

With trimethylsilyl trifluoromethanesulfonate; azobisisobutyronitrile; tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jm9600499