(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

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Chemical Name:(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester
CAS No.:90600-48-9
Molecular Formula:C₃₇H₅₂N₄O₇
Molecular Weight:664.842
Hs Code.:

(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

Synonyms:(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

There total 4 articles about (S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 90600-48-9
(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

2: 100 percent / 4.1M hydrogen chloride / dioxane / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;
DOI:10.1246/bcsj.57.819

Reference yield:

: benzyl (S)-2-((2S,3S)-2-amino-3-methylpentanoylamino)-3-methylbutyrate hydrochloride

: 90600-48-9
(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N-methylmorpholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 10 min, 2) DMF, 1h, ice bath then room temperature overnight

2: 100 percent / 4.1M hydrogen chloride / dioxane / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;
DOI:10.1246/bcsj.57.819

Reference yield:

: 90600-46-7
(S)-2-[(1S,2S)-1-((S)-1-Benzyloxycarbonyl-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 90600-48-9
(S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 4.1M hydrogen chloride / dioxane / 1 h / Ambient temperature

With hydrogenchloride; In 1,4-dioxane;
DOI:10.1246/bcsj.57.819