CID 10330131

Base Information

Chemical Name:CID 10330131
CAS No.:138395-78-5
Molecular Formula:C7H11NO5
Molecular Weight:0
Hs Code.:
Mol file:138395-78-5.mol

Synonyms:138395-78-5;(3aR,4R,5R,6R,6aS)-4,5-dihydroxy-6-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[d][1,3]oxazol-2-one

Suppliers and Price of CID 10330131

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of CID 10330131

Chemical Property:

PSA：99.02000
LogP:-1.86390
XLogP3:-1.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:189.06372245
Heavy Atom Count:13
Complexity:233

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C(C1C(C(C2C1OC(=O)N2)O)O)O
Isomeric SMILES:C([C@@H]1[C@H]([C@@H]([C@@H]2[C@H]1OC(=O)N2)O)O)O

Technology Process of CID 10330131

There total 23 articles about CID 10330131 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138395-72-9
2-aza-7,8-di-t-butyldimethylsiloxy-6-hydroxymethyl-4-oxabicyclo<3.3.0>octan-3-one

: 138395-78-5
(3aR,4R,5R,6R,6aS)-4,5-Dihydroxy-6-hydroxymethyl-hexahydro-cyclopentaoxazol-2-one

Guidance literature:: With hydrogenchloride; In methanol; at 25 ℃; for 2.5h;
DOI:10.1016/S0040-4039(00)92386-4

Reference yield:

: 100021-11-2
(1α,2β,3α)-2-(benzyloxymethyl)cyclopent-4-ene-1,3-diol

: 138395-78-5
(3aR,4R,5R,6R,6aS)-4,5-Dihydroxy-6-hydroxymethyl-hexahydro-cyclopentaoxazol-2-one

Guidance literature:: Multi-step reaction with 12 steps

1: 85 percent / NaH, n-Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: 88 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / Ambient temperature

3: 67 percent / Et₃N / tetrahydrofuran / 0 °C

4: 92 percent / TMSOTf / CHCl₃ / 4 °C

5: 1.) KHMDS, 18-crown-6-ether / 1.) THF, -78 deg C, 2.) THF

6: 91 percent / 10percent aq. HCl / acetone / Ambient temperature

7: pyridine / CH₂Cl₂ / 0 °C

8: Bu₄NN₃ / benzene / Ambient temperature

9: H₂ / Pd/C / methanol / 2280 Torr

10: aq. Na₂CO₃ / CH₂Cl₂ / 0 °C

11: 76 percent / H₂ / Pd(OH)2/C / methanol / 2280 Torr / Ambient temperature

12: MeONa, mol. sieves 4A / methanol / Heating

With pyridine; hydrogenchloride; osmium(VIII) oxide; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; sodium methylate; tetrabutylammoniun azide; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; sodium carbonate; 4-methylmorpholine N-oxide; triethylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone; benzene;
DOI:10.1016/S0957-4166(97)00625-3

Reference yield:

: C₂₇H₂₈O₃

: 138395-78-5
(3aR,4R,5R,6R,6aS)-4,5-Dihydroxy-6-hydroxymethyl-hexahydro-cyclopentaoxazol-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 88 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / Ambient temperature

2: 67 percent / Et₃N / tetrahydrofuran / 0 °C

3: 92 percent / TMSOTf / CHCl₃ / 4 °C

4: 1.) KHMDS, 18-crown-6-ether / 1.) THF, -78 deg C, 2.) THF

5: 91 percent / 10percent aq. HCl / acetone / Ambient temperature

6: pyridine / CH₂Cl₂ / 0 °C

7: Bu₄NN₃ / benzene / Ambient temperature

8: H₂ / Pd/C / methanol / 2280 Torr

9: aq. Na₂CO₃ / CH₂Cl₂ / 0 °C

10: 76 percent / H₂ / Pd(OH)2/C / methanol / 2280 Torr / Ambient temperature

11: MeONa, mol. sieves 4A / methanol / Heating

With pyridine; hydrogenchloride; osmium(VIII) oxide; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; sodium methylate; tetrabutylammoniun azide; potassium hexamethylsilazane; sodium carbonate; 4-methylmorpholine N-oxide; triethylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone; benzene;
DOI:10.1016/S0957-4166(97)00625-3