5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Base Information

Chemical Name:5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone
CAS No.:152660-79-2
Molecular Formula:C₃₁H₃₃N₃O₆
Molecular Weight:543.62
Hs Code.:

Synonyms:5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Suppliers and Price of 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

There total 4 articles about 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 152660-79-2
5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -78 deg C to RT, 3 h

2: 5.7 g / NaIO₄, NaOAc / ethyl acetate; H₂O / 3 h / 0 °C

3: 700 mg / H₂, HOAc, NaOAc / 5percent Pd/C / methanol; H₂O / 8 h / 2585.7 Torr

4: 300 mg / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium periodate; n-butyllithium; hydrogen; sodium acetate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00073a015

Reference yield:

: 152660-73-6
N-(cyclopropylmethyl)-5β-methylnorthebaine

: 152660-79-2
5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Guidance literature:: Multi-step reaction with 3 steps

1: 5.7 g / NaIO₄, NaOAc / ethyl acetate; H₂O / 3 h / 0 °C

2: 700 mg / H₂, HOAc, NaOAc / 5percent Pd/C / methanol; H₂O / 8 h / 2585.7 Torr

3: 300 mg / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium periodate; hydrogen; sodium acetate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00073a015

Reference yield:

: N-(cyclopropylmethyl)-5β-methyl-19-<(2,2,2-trichloroethoxy)carbonyl>-6,14-dihydro-6,14-(epoxyimino)northebaine

: 152660-79-2
5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone

Guidance literature:: Multi-step reaction with 2 steps

1: 700 mg / H₂, HOAc, NaOAc / 5percent Pd/C / methanol; H₂O / 8 h / 2585.7 Torr

2: 300 mg / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogen; sodium acetate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jm00073a015