Technology Process of 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone
There total 4 articles about 5β-methyl-14β-<(p-nitrocinnamoyl)amino>-7,8-dihydro-N-(cyclopropylmethyl)norcodeinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -78 deg C to RT, 3 h
2: 5.7 g / NaIO4, NaOAc / ethyl acetate; H2O / 3 h / 0 °C
3: 700 mg / H2, HOAc, NaOAc / 5percent Pd/C / methanol; H2O / 8 h / 2585.7 Torr
4: 300 mg / Et3N / CH2Cl2 / 3 h / Ambient temperature
With
sodium periodate; n-butyllithium; hydrogen; sodium acetate; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00073a015
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 5.7 g / NaIO4, NaOAc / ethyl acetate; H2O / 3 h / 0 °C
2: 700 mg / H2, HOAc, NaOAc / 5percent Pd/C / methanol; H2O / 8 h / 2585.7 Torr
3: 300 mg / Et3N / CH2Cl2 / 3 h / Ambient temperature
With
sodium periodate; hydrogen; sodium acetate; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00073a015
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 700 mg / H2, HOAc, NaOAc / 5percent Pd/C / methanol; H2O / 8 h / 2585.7 Torr
2: 300 mg / Et3N / CH2Cl2 / 3 h / Ambient temperature
With
hydrogen; sodium acetate; acetic acid; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1021/jm00073a015
