C₂₈H₃₄N₂O₄S

Base Information

• Chemical Name: C₂₈H₃₄N₂O₄S
• CAS No.: 158522-19-1
• Molecular Formula: C₂₈H₃₄N₂O₄S
• Molecular Weight: 494.655
• Mol file: 158522-19-1.mol

Synonyms:C₂₈H₃₄N₂O₄S

Chemical Property of C₂₈H₃₄N₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₄N₂O₄S

There total 4 articles about C₂₈H₃₄N₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

toluene-4-sulfonic acid hydrazide (1576-35-8) + 17β-hydroxy-3-methoxy-14,17α-ethanoestra-1,3,5(10)-triene-16-one (135769-15-2) → C28H34N2O4S (158522-19-1)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 52h;

DOI:10.1016/S0040-4020(01)80652-9

Reference yield:

17-acetyloxy-3-methoxyestra-1,3,5(10),14,16-pentaene (19660-26-5) → C28H34N2O4S (158522-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 32 percent / 2,6-di-t-butyl-p-cresol, mesitylene / 160 deg C, 16 h, 180 deg C, 21 h

2: 82 percent / 2M KOH / H₂O; dimethylsulfoxide; tetrahydrofuran / 0 deg C, 30 min, 20 deg C, 25 h

3: 91 percent / H₂ / 10percentPd/C / ethyl acetate / 3 h / 23 °C

4: 92 percent / TFA / tetrahydrofuran / 52 h / 20 °C

With potassium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; hydrogen; trifluoroacetic acid; 1,3,5-trimethyl-benzene; 10% palladium on active carbon; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/S0040-4020(01)80652-9

Reference yield:

17β-hydroxy-3-methoxy-14,17α-ethenoestra-1,3,5(10)-triene-16-one (135769-00-5) → C28H34N2O4S (158522-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10percentPd/C / ethyl acetate / 3 h / 23 °C

2: 92 percent / TFA / tetrahydrofuran / 52 h / 20 °C

With hydrogen; trifluoroacetic acid; 10% palladium on active carbon; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/S0040-4020(01)80652-9

upstream raw materials:

toluene-4-sulfonic acid hydrazide

17β-hydroxy-3-methoxy-14,17α-ethanoestra-1,3,5(10)-triene-16-one

17-acetyloxy-3-methoxyestra-1,3,5⁽¹⁰⁾,14,16-pentaene

17β-hydroxy-3-methoxy-14,17α-ethenoestra-1,3,5(10)-triene-16-one