3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

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Chemical Name:3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid
CAS No.:1383481-30-8
Molecular Formula:C₂₁H₁₇N₅O₃
Molecular Weight:387.398
Hs Code.:

Synonyms:3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

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Chemical Property of 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

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Technology Process of 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

There total 10 articles about 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1395786-74-9
methyl 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoate

: 1383481-30-8
3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

Guidance literature:: methyl 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=3;

Reference yield:

: 99769-19-4
[3-(methoxycarbonyl)phenyl]boronic acid

: 1383481-30-8
3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / 1,4-dioxane; water / 95 °C / Inert atmosphere

2.1: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 100 °C

3.1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 110 °C / Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 20 °C

5.1: isopropyl alcohol; water / 4 h / 100 °C

6.1: N-iodo-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C

7.1: sodium carbonate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / 1,4-dioxane; water / 100 °C / Inert atmosphere

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

8.2: pH 3

With hydrogenchloride; N-iodo-succinimide; lithium hydroxide monohydrate; water; sodium carbonate; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; trichlorophosphate; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Suzuki Coupling / 7.1: Suzuki Coupling;

Reference yield:

: 787591-43-9
2-(3-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1383481-30-8
3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2.08 h / 0 - 20 °C

2.1: sodium carbonate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / 1,4-dioxane; water / 100 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

3.2: pH 3

With lithium hydroxide monohydrate; water; sodium carbonate; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2.1: Suzuki Coupling;