diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate

Base Information

• Chemical Name: diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate
• CAS No.: 1260226-94-5
• Molecular Formula: C₂₀H₂₄NO₄P
• Molecular Weight: 373.389
• Mol file: 1260226-94-5.mol

Synonyms:diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate

Chemical Property of diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate

There total 2 articles about diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl 2-bromomethylbenzoate (2417-73-4) + [1-(4-amino-phenyl)-ethyl]-phosphonic acid diethyl ester (856997-52-9) → diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate (1260226-94-5) + C21H28NO5P (1260226-95-6)

Guidance literature:

In ethanol; for 60h; Reflux;

DOI:10.1080/10426500903567547

Reference yield: 32.0%

1-chloro [4-(1-oxo-2-isoindolinyl)phenyl]ethane (68327-79-7) → 2-(4-vinylphenyl)isoindolin-1-one + diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate (1260226-94-5)

Guidance literature:

With triethyl phosphite; at 160 ℃; for 16h;

DOI:10.1080/10426500903567547

Reference yield: 100.0%

diethyl 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonate (1260226-94-5) → 1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonic acid (1260226-96-7)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane;

DOI:10.1080/10426500903567547

upstream raw materials:

methyl 2-bromomethylbenzoate

[1-(4-amino-phenyl)-ethyl]-phosphonic acid diethyl ester

1-chloro [4-(1-oxo-2-isoindolinyl)phenyl]ethane

Downstream raw materials:

1-[4-(isoindolin-1-one-2-yl)phenyl]ethylphosphonic acid