Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI)

Base Information

• Chemical Name: Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI)
• CAS No.: 501372-84-5
• Molecular Formula: C10H11N
• Molecular Weight: 145.2
• Mol file: 501372-84-5.mol

Synonyms:Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI)

Chemical Property of Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI)

There total 5 articles about Cycloprop[a]inden-1-amine, 1,1a,6,6a-tetrahydro-, (1R,1aR,6aR)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(trans)-1,1a,6,6a-tetrahydrocycloprop[a]inden-1-carbamic acid tert-butyl ester → (trans)-1,1a,6,6a-tetrahydrocycloprop[a]inden-1-amine (501372-84-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield: 94.0%

→ (cis)-1,1a,6,6a-tetrahydrocyclopropa[a]indene-1-amine (501372-84-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield:

1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid (501418-06-0,59905-94-1,59905-95-2) → endo-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine (501372-84-5)

Guidance literature:

1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 2h; Heating / reflux;

With hydrogenchloride; water; at 20 ℃; for 1h;

upstream raw materials:

1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid

Refernces

• 1、 -. "1,1a,6,6a-tetrahydrocycloprop[a]indene-1-amine derivatives and preparation method and applications thereof". Paragraph 0251; 0256; 0257. . Retrieved 2019/04/10.