N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine

Base Information

• Chemical Name: N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine
• CAS No.: 1354041-52-3
• Molecular Formula: C₃₀H₂₂FN₇O
• Molecular Weight: 515.549
• Mol file: 1354041-52-3.mol

Synonyms:N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine

Chemical Property of N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine

There total 1 articles about N₅-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N5-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine (1354041-52-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; at 110 ℃; for 16h;

Reference yield: 95.0%

N5-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine (1354041-52-3) → 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride (1354041-35-2)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; for 0.333333h;

Reference yield:

N5-(diphenylmethylene)-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine (1354041-52-3) → C23H22FN7O3 (1354043-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran / 0.33 h

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane

With hydrogenchloride; oxalyl dichloride; water; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Downstream raw materials:

2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

C₂₃H₂₄FN₇O₂

C₂₄H₁₈FN₇O₂

C₂₅H₂₀FN₇O₃