[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

Base Information

Chemical Name:[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid
CAS No.:202592-28-7
Molecular Formula:C₁₉H₁₇ClN₄O₂S
Molecular Weight:400.889
Hs Code.:

Synonyms:[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

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Chemical Property of [4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

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Technology Process of [4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

There total 9 articles about [4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [4-(4-chlorophenyl)-6-ethoxycarbonyl-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

: 202592-28-7,202592-23-2
[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

Guidance literature:: With sodium hydroxide; In ethanol;

Reference yield:

: 1268524-69-1
[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraazacyclopenta[e]azulen-6-yl]acetic acid tert-butyl ester

: 202592-28-7,202592-23-2
[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201307803

Reference yield:

: 4640-66-8
p-chlorobenzoylacetonitrile

: 202592-28-7,202592-23-2
[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfur; morpholine / ethanol / 12 h / 70 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / chloroform / 24 h / 40 °C / Inert atmosphere

3.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.1: acetic acid / ethanol / 2 h / 80 °C / Inert atmosphere

5.1: Lawessons reagent / toluene / 4 h / Inert atmosphere; Reflux

6.1: hydrazine hydrate / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere; Cooling with ice

7.1: 1-methyl-pyrrolidin-2-one; isobutyl chloroformate / tetrahydrofuran / 5 h / Inert atmosphere; Cooling with ice

7.2: 12 h / 90 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With piperidine; Lawessons reagent; morpholine; 1-methyl-pyrrolidin-2-one; hydrazine hydrate; benzotriazol-1-ol; sulfur; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201307803