2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile

Base Information

• Chemical Name: 2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile
• CAS No.: 755756-82-2
• Molecular Formula: C₁₇H₁₀FN₃O
• Molecular Weight: 291.284
• Mol file: 755756-82-2.mol

Synonyms:2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile

Chemical Property of 2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile

There total 1 articles about 2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

3-dimethylamino-1-(4-fluorophenyl)-2-(4-pyridyl)-2-propen-1-one (148671-39-0) + cyanoacetic acid amide (107-91-5) → 2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile (755756-82-2)

Guidance literature:

With sodium methylate; In DMF (N,N-dimethyl-formamide); for 1h; Heating / reflux;

Reference yield: 55.0%

2-(4-fluorophenyl)-6-hydroxy-3,4'-bipyridine-5-carbonitrile (755756-82-2) → 6-chloro-2-(4-fluorophenyl)-3,4'-bipyridine-5-carbonitrile

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; for 2h; Heating / reflux;

upstream raw materials:

3-dimethylamino-1-(4-fluorophenyl)-2-(4-pyridyl)-2-propen-1-one

cyanoacetic acid amide