N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Base Information

• Chemical Name: N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide
• CAS No.: 447460-12-0
• Molecular Formula: C₂₃H₁₈ClF₄NO₃S
• Molecular Weight: 499.913

Synonyms:N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Chemical Property of N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

There total 6 articles about N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-[1-(4-{4-chloro-2-[(2-fluoro-phenyl)-hydroxy-methyl]-benzenesulfonyl}-phenyl)-ethyl]-2,2,2-trifluoro-acetamide (447460-11-9) → N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide (447460-12-0)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

Reference yield:

N-{1-[4-(4-chloro-phenylsulfanyl)-phenyl]-ethyl}-2,2,2-trifluoro-acetamide (447460-02-8) → N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide (447460-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 30 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 - 15 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran

3.1: (C₂H₅)3SiH; BF₃*OEt₂ / CH₂Cl₂ / 20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2005.07.023

Reference yield:

N-{1-[4-(4-chlorobenzenesulfonyl)-phenyl]ethyl}-2,2,2-trifluoroacetamide (447460-00-6) → N-(1-{4-[4-chloro-2-(2-fluoro-benzyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide (447460-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: (C₂H₅)3SiH; BF₃*OEt₂ / CH₂Cl₂ / 20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2005.07.023

upstream raw materials:

N-[1-(4-{4-chloro-2-[(2-fluoro-phenyl)-hydroxy-methyl]-benzenesulfonyl}-phenyl)-ethyl]-2,2,2-trifluoro-acetamide

N-{1-[4-(4-chloro-phenylsulfanyl)-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

N-{1-[4-(4-chlorobenzenesulfonyl)-phenyl]ethyl}-2,2,2-trifluoroacetamide

(S)-1-phenyl-ethylamine

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