4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 550371-76-1
• Molecular Formula: C15H22N2O2
• Molecular Weight: 262.35
• Hs Code.: 2933990090
• Mol file: 550371-76-1.mol

Synonyms:4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 371℃
• Flash Point: 178℃
• PSA: 42.43000
• Density: 1.083
• LogP: 3.13400

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(pyridin-4-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 6 articles about 4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(piperidin-4-yl)pyridine (581-45-3) + di-tert-butyl dicarbonate (24424-99-5) → Boc-4-pyridin-4-yl-piperidine (550371-76-1)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 1h;

Reference yield: 81.0%

1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (1872262-73-1) + C13H18NO4(1+)*C2H5O4S(1-) → Boc-4-pyridin-4-yl-piperidine (550371-76-1) + 3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester (206446-49-3)

Guidance literature:

1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate; C₁₃H₁₈NO₄⁽¹⁺⁾*C₂H₅O₄S^(1-); With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; In N,N-dimethyl acetamide; at 25 ℃; for 10h; Inert atmosphere; Irradiation;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 25 ℃; for 0.5h; regioselective reaction;

DOI:10.1039/d2ob00123c

Reference yield:

tert-butyl 5,6-dihydro-[4,4'-bipyridine]-1(2H)-carboxylate (1000211-91-5) → Boc-4-pyridin-4-yl-piperidine (550371-76-1)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 ℃; for 1h; under 2280.15 Torr;

upstream raw materials:

tert-butyl 5,6-dihydro-[4,4'-bipyridine]-1(2H)-carboxylate

4-(piperidin-4-yl)pyridine

di-tert-butyl dicarbonate

1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate

Downstream raw materials:

4-(piperidin-4-yl)pyridine

Refernces

• 1、 -. "INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE ("NACK") AND METHODS FOR USE OF THE SAME". Paragraph 00151. . Retrieved 2019/08/29.
• 2、 -. "DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR". Page/Page column 34. . Retrieved 2010/12/31.