methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate

Base Information

• Chemical Name: methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate
• CAS No.: 135226-89-0
• Molecular Formula: C₃₀H₃₂N₂O₇
• Molecular Weight: 532.593

Synonyms:methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate

Chemical Property of methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate

There total 8 articles about methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-N,O-dimethyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester (135226-84-5) → methyl 4-methoxy-12-amino>-N10-methyl-11-oxo-2-azatricyclo<12.2.2.13,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate (135226-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 6 h / 25 °C

2: EDCI, HOBt*H₂O / dimethylformamide / 16 h / 25 °C

3: 1.) NaH, CuBr-SMe₂ / 1.) collidine, 25 deg C, 0.5 h, 2.) collidine, 130 deg C, 9 h

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00062a004

Reference yield:

3-acetyl-N,O-dimethyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester (135226-82-3) → methyl 4-methoxy-12-amino>-N10-methyl-11-oxo-2-azatricyclo<12.2.2.13,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate (135226-89-0)

Guidance literature:

Multi-step reaction with 5 steps

1: m-chloroperbenzoic acid (mCPBA) / CH₂Cl₂ / 24 h / 40 °C

2: HCl / methanol / 3 h / 25 °C

3: H₂ / 10percent Pd/C / methanol / 6 h / 25 °C

4: EDCI, HOBt*H₂O / dimethylformamide / 16 h / 25 °C

5: 1.) NaH, CuBr-SMe₂ / 1.) collidine, 25 deg C, 0.5 h, 2.) collidine, 130 deg C, 9 h

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00062a004

Reference yield:

(S)-3-(3-Acetoxy-4-methoxy-phenyl)-2-(benzyloxycarbonyl-methyl-amino)-propionic acid methyl ester (135226-83-4) → methyl 4-methoxy-12-amino>-N10-methyl-11-oxo-2-azatricyclo<12.2.2.13,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate (135226-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / methanol / 3 h / 25 °C

2: H₂ / 10percent Pd/C / methanol / 6 h / 25 °C

3: EDCI, HOBt*H₂O / dimethylformamide / 16 h / 25 °C

4: 1.) NaH, CuBr-SMe₂ / 1.) collidine, 25 deg C, 0.5 h, 2.) collidine, 130 deg C, 9 h

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00062a004

upstream raw materials:

(S)-2-{[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-iodo-phenyl)-propionyl]-methyl-amino}-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

N,O⁴-dimethyl-L-DOPA methyl ester

4-iodo-N-methyl-N-<(phenylmethoxy)carbonyl>-L-phenylalanine

L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester

Downstream raw materials:

deoxybouvadin

RA-VII

C₄₆H₆₀N₆O₁₂

BOC-D-alanyl-L-alanyl-N,O-dimethyl-L-tyrosyl-L-alanyl-N-methyl-L-tyrosyl-N,O-dimethyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 135226-89-0 methyl 4-methoxy-12-amino>-N¹⁰-methyl-11-oxo-2-azatricyclo<12.2.2.1^3,7>nonadeca-3,5,7(19),14,16,17-hexaene-9-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send