2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile

Base Information

• Chemical Name: 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile
• CAS No.: 130485-17-5
• Molecular Formula: C₂₅H₂₂N₂O
• Molecular Weight: 366.462
• Mol file: 130485-17-5.mol

Synonyms:2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile

Chemical Property of 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile

There total 6 articles about 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-Cyano-2-(4-methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester (130485-03-9) → 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile (130485-10-8) + 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile (130485-17-5)

Guidance literature:

With piperidine; In toluene; for 48h; Title compound not separated from byproducts; Heating;

DOI:10.1016/S0040-4020(01)81520-9

Reference yield:

methyl (E)-2-cyano-3-phenylprop-2-enoate (14533-86-9) → 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile (130485-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / 0.5 h / Heating

2: 70 percent / piperidine / toluene / 48 h / Heating

With piperidine; acetic anhydride; In toluene;

DOI:10.1016/S0040-4020(01)81520-9

Reference yield:

[(4-methoxy-benzoyl)-methyl-amino]-phenyl-acetic acid (28544-46-9) → 2-(4-Methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carbonitrile (130485-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Ac₂O / 0.5 h / Heating

2: 70 percent / piperidine / toluene / 48 h / Heating

With piperidine; acetic anhydride; In toluene;

DOI:10.1016/S0040-4020(01)81520-9

upstream raw materials:

3-Cyano-2-(4-methoxy-phenyl)-1-methyl-4,5-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester

methyl (E)-2-cyano-3-phenylprop-2-enoate

[(4-methoxy-benzoyl)-methyl-amino]-phenyl-acetic acid

(benzoyl-methyl-amino)-(4-methoxy-phenyl)-acetic acid