9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

Base Information

Chemical Name:9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide
CAS No.:1187617-58-8
Molecular Formula:C₂₆H₁₈FN₅O
Molecular Weight:435.46
Hs Code.:

Synonyms:9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

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Chemical Property of 9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

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Technology Process of 9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

There total 8 articles about 9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1187617-57-7
9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid

: 1187617-58-8
9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

Guidance literature:: With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 93583-49-4
methyl carbazole-4-carboxylate

: 1187617-58-8
9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

2.1: potassium carbonate / copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 1.5 h / 160 °C / microwave irradiation

3.1: methanol; lithium hydroxide monohydrate / 2 h / Reflux

4.1: sodium hydroxide; methanol / 20 °C / Reflux

4.2: 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3 h / 20 °C

With methanol; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; lithium hydroxide monohydrate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; petroleum jelly; N,N-dimethyl-formamide;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1187617-58-8
9-(3-amino-4-cyanophenyl)-9H-carbazole-4-carboxylic acid (2-amino-4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / 1500.15 Torr / autoclave

3.1: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

4.1: potassium carbonate / copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 1.5 h / 160 °C / microwave irradiation

5.1: methanol; lithium hydroxide monohydrate / 2 h / Reflux

6.1: sodium hydroxide; methanol / 20 °C / Reflux

6.2: 0.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3 h / 20 °C

With methanol; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; lithium hydroxide monohydrate; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; petroleum jelly; dichloromethane; N,N-dimethyl-formamide;