ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

Base Information

Chemical Name:ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate
CAS No.:1299483-22-9
Molecular Formula:C₂₁H₁₅ClF₆N₂O₃
Molecular Weight:492.805
Hs Code.:

Synonyms:ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

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Chemical Property of ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

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Technology Process of ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

There total 3 articles about ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65686-68-2,1213368-14-9,1213841-80-5
2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine

: 1299483-21-8
6-chloro-5-(ethoxycarbonyl)-1H-indole-2-carboxylic acid

: 1299483-22-9
ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

Reference yield:

: 16017-69-9
ethyl-2-chloro-4-amino-benzoate

: 1299483-22-9
ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: iodine / ethanol / 0.75 h / 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 96 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; iodine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium diacetate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1057076-51-3
ethyl 4-amino-2-chloro-5-iodobenzoate

: 1299483-22-9
ethyl 6-chloro-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 96 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium diacetate; In N,N-dimethyl-formamide;