(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

Base Information

Chemical Name:(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime
CAS No.:214043-17-1
Molecular Formula:C₃₄H₃₃F₄NO₆
Molecular Weight:627.633
Hs Code.:

Synonyms:(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

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Technology Process of (2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

There total 4 articles about (2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (3R,4S,5R,6R)-3,4,5-Tris-(4-fluoro-benzyloxy)-6-(4-fluoro-benzyloxymethyl)-tetrahydro-pyran-2-ol

: 214043-17-1
(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium methylate; In methanol; at 60 ℃; for 7h;
DOI:10.1002/hlca.19980810546

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 214043-17-1
(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / NaH / dimethylformamide / 0.75 h / 0 - 25 °C

2: 52 percent / 1M H₂SO₄ / acetic acid / 2 h / Heating

3: 97 percent / NH₂OH*HCl, NaOMe / methanol / 7 h / 60 °C

With sulfuric acid; hydroxylamine hydrochloride; sodium methylate; sodium hydride; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19980810546

Reference yield:

: 214043-14-8
(2R,3R,4S,5R,6S)-3,4,5-Tris-(4-fluoro-benzyloxy)-2-(4-fluoro-benzyloxymethyl)-6-methoxy-tetrahydro-pyran

: 214043-17-1
(2S,3R,4R,5R)-2,3,4,6-Tetrakis-(4-fluoro-benzyloxy)-5-hydroxy-hexanal oxime

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / 1M H₂SO₄ / acetic acid / 2 h / Heating

2: 97 percent / NH₂OH*HCl, NaOMe / methanol / 7 h / 60 °C

With sulfuric acid; hydroxylamine hydrochloride; sodium methylate; In methanol; acetic acid;
DOI:10.1002/hlca.19980810546