N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Base Information

Chemical Name:N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine
CAS No.:86778-88-3
Molecular Formula:C₃₃H₄₆N₆O₇
Molecular Weight:638.764
Hs Code.:

Synonyms:N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Suppliers and Price of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Chemical Property:

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Technology Process of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

There total 7 articles about N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-N^ω-nitro-L-arginine

: 86778-88-3
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; under 3102.9 Torr; Yield given;
DOI:10.1021/jm00369a017

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 86778-88-3
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

2: 2.5 N NaOH / methanol / 25 °C

3: H₂, AcOH / 10percent Pd/C / ethanol / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017

Reference yield:

: 64665-60-7
DL-α-methylphenylalanine methyl ester hydrochloride

: 86778-88-3
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanyl-L-arginine

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

2: 96 percent / 2.5 N NaOH / methanol / 25 °C

3: 39 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

4: 2.5 N NaOH / methanol / 25 °C

5: H₂, AcOH / 10percent Pd/C / ethanol / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017