dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

Base Information

Chemical Name:dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate
CAS No.:635310-43-9
Molecular Formula:C₁₅H₂₁O₄P
Molecular Weight:296.303
Hs Code.:

Synonyms:dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

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Chemical Property of dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

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Technology Process of dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

There total 3 articles about dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 4535-96-0
1-phenyl-1-cyclopentanecarboxylic acid methyl ester

: 756-79-6
dimethyl methane phosphonate

: 635310-43-9
dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-phenyl-1-cyclopentanecarboxylic acid methyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 2.16667h;

Reference yield:

: 17380-62-0
1-phenylcyclopentanecarboxylic acid chloride

: 756-79-6
dimethyl methane phosphonate

: 635310-43-9
dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

With copper(l) iodide; In tetrahydrofuran; hexane; at -30 ℃; for 0.166667h;

1-phenylcyclopentanecarboxylic acid chloride; In tetrahydrofuran; hexane; at 20 ℃; for 20h;
DOI:10.1002/chem.201801804

Reference yield:

: 77-55-4
1-phenyl-1-cyclopentanecarboxylic acid

: 635310-43-9
dimethyl 2-[1-(phenyl)cyclopentyl]-2-oxoethyl phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 - 40 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 0.17 h / -30 °C

2.3: 20 h / 20 °C

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201801804