tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Base Information

Chemical Name:tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate
CAS No.:241478-40-0
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Suppliers and Price of tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

There total 20 articles about tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 241478-36-4
tert-butyl-(1S,2R)-N-[2-hydroxy-1-(hydroxymethyl)-3-phenylacetylenyl]carbamate

: 241478-40-0
tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; toluene; for 24h; Ambient temperature;
DOI:10.1021/jm990091e

Reference yield:

: 241478-33-1
tert-butyl (4S)-4-<(1R)-1-hydroxy-3-phenyl-2-propynyl>-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 241478-40-0
tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / TosOH; MeOH / 20 °C

2: 68 percent / Red-Al / diethyl ether / 0 - 20 °C

With methanol; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; 1: Ring cleavage / 2: Hydrogenation;
DOI:10.1016/S0960-894X(99)00554-5

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 241478-40-0
tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / n-BuLi; HMPA / tetrahydrofuran / -78 °C

2: 67 percent / TosOH; MeOH / 20 °C

3: 68 percent / Red-Al / diethyl ether / 0 - 20 °C

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; 1: Addition / 2: Ring cleavage / 3: Hydrogenation;
DOI:10.1016/S0960-894X(99)00554-5