3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

Base Information

Chemical Name:3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine
CAS No.:1173243-10-1
Molecular Formula:C₄₀H₄₇N₉O₅
Molecular Weight:733.87
Hs Code.:

Synonyms:3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

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Chemical Property of 3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

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Technology Process of 3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

There total 1 articles about 3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173243-09-8
C₄₁H₄₆F₃N₉O₇S

: 1173243-10-1
3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

Guidance literature:: With 18-crown-6 ether; potassium trifluoroacetate; N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 2.5h; Inert atmosphere;

Reference yield: 96.0%

: 1173243-10-1
3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

: Fmoc-L-Thr(TBMDS)-OH

: C₆₅H₈₀N₈O₉Si

Guidance literature:: Fmoc-L-Thr(TBMDS)-OH; With 1-hydroxy-1H-benzotriazole hydrate; diisopropyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine; With trimethylphosphane; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201302188

Reference yield: 93.0%

: 1173243-10-1
3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

: 146346-81-8,201210-25-5
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)propanoic acid

: 1529796-58-4
6-N-[(di-n-butylamino)methylene]-3'-{[N-(9-fluorenyl)methoxycarbonyl-O-(tert.-butyldimethylsilyl)-L-serinyl]amino}-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine

Guidance literature:: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)propanoic acid; With 1-hydroxy-1H-benzotriazole hydrate; diisopropyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine; With trimethylphosphane; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201302188